The results of experimental studying izoforms of CYP450, which catalyze N1-dealkylation and C3-hydroxylation were shown. The results of the experiment revealed that pharmacokinetics parameters of hydasepam (t1/2, Cl, C0, k and MRT) change in dependance on type of inductor (phenobarbital) or inhibitor (omeprasole, ketokonasole) CYP450, which were introducted before hydazepam. The obtained results can show interaction of hydasepam with other drugs — substances, inductors and inhibitors CYP3A4 and CYP2C19.
