The aim of this work is studying the penetration processes of 7-brom-5(о-chlor) phenil-1,2-dihydro-3Н-1,4-benzdiazepine-2-on through stratum corneum in vitro and dynamics of accumulation of this substance in the mice skin in vivo when administered transdermally. In in vitro experiments the linear increase of benzdiazepine quantity, passing through the stratum corneum, had place from 3 to 18 h after application and after this period trend to hold the reached level of concentration. In vivo experiments have shown that drug quantity in the skin approaches stationary level during 6 h after TTS application; increase in TTS drug concentration leads to its augmentation in the skin.
