In rats in which resistant form of experimental sizure syndrome was induced via corazol kindled administrations, the dynamics of focal epileptogenesis was investigated, which was induced in left ventral hippocampus via microinjection of sodium salt of benzilpenicillin, NMDA, kainic acid and strychnin nitrate. It was established that seizure susceptibility to epileptogenic effects of NMDA and kainic acid was raised. The net decreasing of susceptibility to NMDA effects were registered after pentoxyphyllin administration, which reduced elaboration of endogenous proinflammatory cytokines.
