It is given a review of novel insulin analogues of short action (insulin lispro, aspart, and glulisin) and long action (detemir, glargin). Short-acting insulins provide rapid and short-time peak of insulin concentration in blood that substitute prandial insulin in diabetic patients. In the same time, long-acting insulins provide long and stable insulin concentration in blood, that is why satisfactory replace basal insulin. In the article one can find data about high effectiveness and low rate of side effects of the insulin analogues in diabetic patients comparatively to previous insulin preparations. The review gives evidences of superiority of continuous subcutaneous insulin injection (CSII) in diabetic patients over multiple day insulin injections. It is due to the fact, that CSII provides release of prandial and basal insulin close to fluctuation of normal insulin.
