New convenient methods for the preparation with 18-crown-6-complex as catalyst of original heterocycles on the base of 6-methyluracile and fluoric containing sintones.
Molecular complex of the bis derivative of 6-methyluracile and antitumour bacterial lectine Bacillus polymyxa 102 KGU was obtained.
A strongly antitumour effect of bis derivative of 6-methyluracile on the heterotransplantates of human glioma cancer with percents of growth relaxation of cancer 30,41% has been revealed (the criteria of importance ≥ 25%). A strongly antitumour effect of molecular complex (bis derivative of 6-methyluracile — bacterial lectine Bacillus polymyxa 102 KGU) on Lymphosarcoma Plissa tumour with growth relaxation of tumour mass 62,0% (the criteria of importance ≥ 50%) has been registered.