Influence of 5-fluorouracil on morphological indexes of rat’s oral mucosa in alimentary polyphenolic deficit was researched. Polyphenolics-free diet promotes increasing of pathological effects of 5-fluorouracil on mucosa. They manifested as disorder of processes of differentiation laminated epithelium and increasing of destructive changes combined with inhibition of cells proliferation. As a result of cell’s dysadaptation formation of pathological mitosis forms, including mitosises with breech of principle of chromosome’s even distribution was detected.
