The changes of TNF-α, IFN-γ, IL-10 level in the spleen, brain and blood serum of mice with the experimental allergic encephalomyelitis were studied after tilorone administration. Tilorone had shown an immunomodulating effect, increasing anti-inflammatory IL-10 level and decreasing TNF-α, IFN-γ level in all studied tissues on different terms after EAE induction.
