The influence of high-frequency electrical stimulation, administrations of isopicamilon and carbamazepine on the development of the regular interictal spikes (IS) in the rat’s frontal cortex and hippocampus on the epileptiform activity generation in a penicillin model were investigated. Ictal discharge generation after high-frequency electrical stimulation was prevented by generation of the regular IS. The activation of the regular epileptiform cortical IS was observed after injection of isopicamilon only during depression of IS in the hippocampus. Carbamazepine demonstrated the IS amplitude reduction without changing frequency.
