Under hibernation conditions chymase activity in adult hamsters-males changes specifically in tissues, in 2 hrs organism renewal increases in most tissues, except for the cerebellum, in 24 hrs — in the cerebral cortex (CC), hypothalamus, brain stem (BS) and liver, that can favor vasoconstriction development. The tonin activity under hibernation conditions increases in the blood serum, declines in the heart, that can cause the constriction reduction, relaxation of cardiac activity, in 2 hrs of renewal it increases in CC, declines in hipotalamus. Calpains activity to the hibernation are increased in the BS, lungs, liver and kidneys, that is considered as a result of oxidative stress, declines in the heart, that is connected with relaxation of cardiac activity which is fully normalized at the stage of organism renewal.
