In acute experiments on Wistar male rats it was established that bacterial lypopolysaccharide (LPS) (0.1 mg/kg, i. p.) — induced antiseizure effects, which are observed on focal forms of epileptic activity in 12–14 h from the moment of LPS administration, was blocked by NO-synthase inhibition via L-NAME administration (50.0 mg/kg, i. p.). L-arginine (500.0 mg/kg, i. p.) caused the enhancement of antiepleptic action of LPS. Mentioned effects were observed on focal model of epilepsy, which was induced via different epileptogens (benzylpenicillin, kainic acid, bicuculline, strychnine) administration into ventral hippocampal structures.
