The aim of this research was to estimate influence of the inherited factors on forming hyperhomocysteinemia (HHcyE) for pregnant women with preeclampsia (PE). Cohort research was conducted with pregnant women with established PE of different degree of severity (main group, n=172) and pregnant women without pathology (control group, n=95). It was determined the level of homocystein in plasma by the method of high-efficiency liquid chromatography and polymorphism in the gene MTHFR 677C3T. It is established the mutations of gene MTHFR associate with the increase of risk of PE, the ratio is 1.35 (0.47–3.95; CІ 95%).
