In experiments on rats corazol kindling (25.0 mg/kg, i.p. daily injection during 21 days), the decreasing of the weight of spleen, thymus along with simultaneous increasing of the weight of suprarenal glands and enlargement of the cortical and medullar layers have been seen. Besides, heightened level of corticotropin, corticosteron and gastrin have been registered in blood. It was established that ketogenic diet (80% of lipids, 3.35 carbohydrates and 16.7% of proteins) prevented kindling-induced deteriorations and this effect was more pronounced in case of four weeks of ketogenic diet treatment.
