Effects of systemic administration of isopicamilon (IP) and picamilon (P) on the frequency and duration of the picrotoxin-induced generalized activity in the rat’s frontal cortex, mediodorsal thalamus and ventral hippocampus were investigated. IP and P in dose of 50 mg/kg increased generalized activity during first 5–10 minutes after their administration. The maximum intensity of seizures with significant increasing frequency and duration of epileptiform convulsive discharges were registered after injection of IP. It was shown that P and, especially, IP didn’t reveal anticonvulsive effects in the model of generalized spike-wave discharges. The generation of cortical individual spikes was observed in 17.5% rats during the formation of the generalized epileptiform activity. The depression of spikes wasn’t observed after injection of P. The increasing of the spike’s frequency was accompanied only with ear and facial twitching and myoclonic contractions of body.
