The aim of the study was a comparative analysis of the impact of immunomodulators amixin, imunofan and polioxydonium on integrated indicators oxidant-antioxidant homeostasis in lymphocytes of animals during course doxorubicin administration. There were found that against doxorubicin-induced oxidative stress inhibition of lipid peroxidation in rat mesenteric lymph nodes in prophylactic administration of immunomodulators amixin, imunofan and polioxydonium ensured the preservation of high activity of various components of the antioxidant system, as enzyme and nonenzyme origin. Expression of the antioxidant effect of each drug is different and depends on the number of injections of doxorubicin and duration of concomitant immunotherapy. In comparative terms the most powerful antioxidant stabilizing influence, especially on the background of prolonged use of doxorubicin, showed immunomodulator polyoxidonium.
