Actual problem in modern gynecology are infectious and inflammatory diseases of the genital tract, the most common of which is non-specific vaginitis. Etiologic factor of the last is mixed infection. Today among a variety of antifungal agents for systemic use there are applied azoles derivatives, which are fungi resistant. Terbinafine is an alilamins derivative. There have been no vaginal drugs with this active ingredient before. At the model of experimental traumatic-bacterial and fungal vaginitis it was proved a therapeutic effect of new combined vaginal cream, which includes antimycotic terbinafine and antibiotic clindamycin, which is not inferior to the pharmacological action of the comparison drug — “Vagiklin”. Indices of vaginitis pathological manifestations regression, such as redness, swelling of the mucous membrane, eroded lesions had the same dynamics as that of the animals treated with the reference drug. This gives grounds for further clinical study of a new cream and its introduction in the gynecological practice.
