The review presented a new perspective on the mechanisms of adaptation under conditions of limiting physical activity and role in the process of hemostasis. It is shown that physiological and pathogenic role in the hemostatic system changes that occur under conditions of stress and limit physical activity, should be considered from the standpoint of new ideas about the coagulation and fibrinolysis system as a more complex thrombin-plasmin system (TPS). According to new ideas TPS exists and operates in all environments of the body — in the blood, interstitial connective tissue and cells, and takes part in providing structural and functional homeostasis of the organism.
