The results of the performed studies showed that growth factors levels indicators determination combined with fetometry, Doppler ultrasound monitoring of blood flow, cardiotocography allows to predict the development and to assess the severity of fetal growth retardation. During fetal growth retardation formation a decrease in the production of type I insulin-like growth factor and placental growth factor, a sharp increase in vascular endothelial growth factor and its receptor are observed. At critical condition with severe fetal malnutrition and hypoxia the level of placental growth factor decreases by 52.57–72.84% over the course of gestation. The pregnant women with critical state of the fetus subsequent development have from 16–22 weeks 4 times increase of the soluble receptor of type I vascular endothelial growth factor level. The obtained results are to be used in order to predict the placental dysfunction and fetal growth retardation in women with high risk pregnancy.
