The functional activity of progenitor cells in the bone marrow under the first-line tyrosine kinase inhibitors therapy was investigated. The results show that there is a correlation between Sokal index, calculated at the time of diagnosis, and the number of colonies in cell culture in vitro for patients who were treated with tyrosine kinase inhibitors therapy. The higher the rate of Sokal index, the greater the number of colonies detected in culture. The dependency between Sokal index and the number of clusters in culture in vitro has not been identified.
