The inhibition of active avoidance, which was induced be maximal electroshock (MES) seizures, have been successfully blocked by levetiracetam and electrical stimulation (ES) of paleocerebellar cortex (100 Hz). ED50 of levetiracetam, which protected active avoidance in 50% of rats in post-MES period was 179.6 mg/kg, i. p., while number of cerebellar ES which caused the similar effect was 15.4 trials. Under condition of ES of paleocerebellum (6 trials of ES) was followed by reduction of levetiracetam ED50 by 4.25 times pertained to value determined for single levetiracetam usage. Combined usage of ES and levetiracetam revealed potentiative character of action.
