PATHOGENIC PROPERTIES OF GENUS VIBRIO AND THEIR ROLE IN ACUTE ENTERIC INFECTIONS

Study of genus Vibrio pathogenic bacteria genome evolution showed that the majority of variations in the biological properties of human vibriosis pathogens are based on DNA structural changes in the bacteria related to virulent genome block acquisition as a result of horizontal gene transfer by mobile genomic elements (MGE). This evolution led to appearance of new virulent species — V. cholerae O1 El Tor biotype, V. cholerae O139, V. parahaemolyticus O3:K6. Some virulent representatives of genus Vibrio, which cause single cases as well as outbreaks of acute enteric infections (AEI), circulate in the environment of Ukraine. Epidemiological AEl situation in Ukraine can be aggravated only by ecdemic virulent vibrios. Usually, establishment of cholera vibrios in southern water areas of Ukraine, circulation of vibrio species with various pathogenic potential, MGE presence and favourable climate conditions can contribute to formation of local vibriosis pathogen clones with various pathogenic potential.