The quality of life was determined in 102 patients who suffered from complex partial and secondarily generalized seizure fits in accordance to МOS SF-36 questionnaire in 24 weeks from the moment of start of mono-pharmacotherapy. The topiramate, lamotrigine and valproates induced the improvement detected by two scales out of eight of mentioned questionnaire. Carbamazepine-induced improvement was shown on three scales while levetiracetam caused improvement detectable by four scales. Most pronounced improvement, which was seen on seven scales was induced by combined usage of levetiracetam and nicotinamide. The antiseizure effects were also most pronounced in the group of patients treated with combination of levetiractem and nicotinamide and the number of positive results of treatment increased in the row of drugs: topiramate, levetiracetam, valproates, lamotrigine and carbamazepine.
