Rats brain reactivity was estimated in conditions of two chronic epileptic activity models — picrotoxin-induced kindling and pilocarpine-provoked seizures — interseizure period. The expression of postural behavioural syndrome was tested in dynamics: directly after seizures termination, in the middle and at the end of non-convulsive period. Postural behavioural syndrome structure was established to have changes in the both picrotoxin- and pilocarpine-induced seizures non-convulsive period dynamics manifested by primarily postural and muscular changes, pain sensitivity and ocular symptoms differences. Kindling rats postural syndrome architecture during the non-convulsive period showed opioid mechanisms substitution by neuroleptic ones which at the end of the ‘postkindling’ period again were alternated by opioids. The authors concluded that the animals brain reactivity in conditions of chronic seizures has dynamic character and appears to have the balance between neuroleptic and opioid mechanisms.
