Forming the hypothesis of primary endothelial dysfunction (ED) in the structuring of dyslipidemic patterns, 102 patients with arterial hypertension and concomitant obesity were examined. The correlation between genetic polymorphisms of the eNOS gene, as predictors of ED, and types of dyslipidemia was studied. A high frequency of isolated G894T polymorphism and combination of T(-786)C and G894T polymorphisms were observed compared to isolated T(-786)C polymorphism and “normal genotypes” of eNOS gene. The dominant types of dyslipidemias were types IIa, IIb, and III, which have high levels of atherogenicity, but no significant predominance of any type of dyslipidemia have been identified. However, in the research a high correlation between dyslipidemic patterns and “pathological” genotypes of eNOS gene polymorphisms was found. The most unfavorable polymorphism of eNOS gene, which is associated with dyslipidemias of high cardiovascular risk, is the combination of “pathological” genotypes of T(-786)C and G894T polymorphisms. It indicates an association of endothelial dysfunction and its genetic markers with the formation of definite patterns of dyslipidemia.
