PECULIARITIES OF ANGIOGENESIS IN TESTICULAR GERM CELL TUMORS

The purpose of the work was to study vascularization in the testicular postpubertal-type yolk sac tumor (YSTPT), postpubertal-type teratoma (TPT), spermatocytic tumor (ST) and teratoma with somatic-type malignancy (TSTM). The relative area (S) and intensity (L) of CD31 and CD34 expression, as well as the density of blood vessels (DBV) were investigated. At progression of YSTPT S of CD31, CD34 expression and DBV have been increasing. In TPT, in the dynamics of tumor progression, DBV and S of CD34 expression have been decreasing and S of CD31 expression increasing. Vascular invasion and metastasis in YSTPT are mediated by an increase of S of CD31 and CD34 expression, as well as an increase of DBV, and in TPT, by an increase of S and L of CD31 expression.