Chronic obstructive pulmonary disease (COPD) is one of the most serious social and economic health problems worldwide. The leading place in the structure of professional diseases in Ukraine is occupied by diseases of the bronchopulmonary system. Among them, and COPD professional etiology. Most diseases are associated with damage to the cell membranes. It is of interest to study the metabolism of membrane lipids in pulmonary pathology. In this regard, the purpose of our work was to study the fatty acid composition of erythrocyte membranes in severe COPD of professional etiology. Using gas- liquid chromatography methods, the determination of the fatty acid content of erythrocytic membranes was carried out. It has been shown that in COPD of a professional etiology of a severe course in the erythrocyte membranes a modification of the fatty acid composition occurred. Saturated and (n-6) polyunsaturated fatty acids accumulated. While among (n-3) polyunsaturated fatty acids, a decrease in their content was observed. The findings indicate that disorders in the lipid composition of cell membranes play an important role in the pathogenesis of COPD professional etiology.
