Electric stimulation (ES) of nervus vagus (50 Гц, 0.5 — 0.8 mА, impulse duration — 0.5 ms, duration of ES trial — 5.0 s) prevented the generalized clonic-tonic seizure fits, induced with pentylenetetrazol (PTZ) (30.0 mg/kg, i. p.) in kindled rats. Multiple regression analysis of electrocorticogram revealed that before ES the left hemisphere contributed mainly to mutual positive functional connections establishing between brain structures which were under investigation. The epileptic system creation based on exclusively mutual positive connections was observed at the height of epileptic activity development which was characterized by synchronized generation of spikes in all brain structures. Nervus vagus ES caused the appearance of negative links between cerebellum (culmen, lobula VI) and the neocortex of both hemisheperes. This result is in favor for the involvement of cerebellar structures into the control of brain excitability and suppression of epileptic activity caused by nervus vagus ES.
