The purpose of the work is to investigate the effect of intermittent normobaric hypoxia (INH) on the morphofunctional state of the lungs tissue of spontaneously hypertensive rats (SHR line). The study was conducted on 24 male rats, which were daily given (during 28 days) a hypoxic gas mixture (12% O2) in a intermittent mode: 15 minutes deoxygenation / 15 min reoxygenation for 2 hours. Morphofunctional changes in the lungs were studied using morphological and biochemical methods. It was found that after the effects of INH in rats, there was a decrease in the size of the alveoli. However, their number and density of location per unit area increased, indicating an increase in the total area of the alveolar surface and the activation of gas exchange processes. In experimental rats, there was a significant decrease in the thickness of the interalveolar membrane, a tendency to decrease oxyproline in the lungs, which may indicate a decrease in the number of connective tissue elements and an improvement in the alveolar-capillary exchange of gases.
