The aim of investigation was to study the activity of acetylcholinesterase in the neobladder at 3, 6, and 12 months after ileocystoplasty. Experimental studies were conducted on 21 mini-pigs females. The age of mini-pigs was from 6 to 14 months. The duration of the experiment was 12 months. Acetylcholinesterase plays an important role in the processes of neurohumoral and synaptic transmission. The inhibited AChE makes the transmission of nerve impulses reduce due to the fact that the release of acetylcholine receptors occurs slowly (only through diffusion). The peculiarities of the activity of acetylcholinesterase can be explained by the denervation syndrome, a complex of changes that occur in postsynaptic neurons, organs and tissues after fallout of the nervous influence on these structures. The main manifestation of the denervation syndrome of myocytes is the disappearance of the end plate, the appearance of new acetylcholine receptors along the entire length of the muscle fiber.
