The aim of this work was to compare Mildronate (meldonium) and Thiotriazolinum (as reference hepatoprotector) effects on the liver with alcohol hepatitis model, as well as the meldonium antidotal action determination for acute ethanol toxicity.
It was established that meldonium in therapeutic doses did not differ from reference preparation thiatriazoline as for hepatoprotective activity. The protective index of meldonium for acute ethanol toxicity was 1.42.