There were examined 49 miners with respiratory system diseases (RSD) (selicose and anthracosis) operated on for acute calculous cholecystitis.
After LCE there was an increasing of RD, manifested by reducing of FVC, Sa, PaO2 and increasing of PaSO2 against increasing of levels of FN and ET-1 in blood plasma. After LtCE indicators of Sa, pH, PaCO2 and PaO2 were not significantly changed. In both groups the original indices of EDVD were significantly lower than in control group. In patients with RSD with RI III degree to perform LCE is inexpedient because of the high risk of RD. The level of ET-1 < 1 ng/l is prognostically safe in LCE in the development of RD in patients with acute calculous cholecystitis and associated RSD.