The aim of given work is to study the analgesic properties of previously synthesized 1-alkyl-3-acetoxy-1,2-dihydro-3H-1,4-benzodiazepine-2-ones.
Analgesic activity was studied in vivo in mice on a model of “writhing” caused by intraperitoneal injection of acetic acid solution and in formalin test. The diclofenac sodium was used as the standard preparation.
There was found a high analgesic activity for the novel compounds of 1-alkyl-3-acetoxy-1,2-dihydro-3H-1,4-benzodiazepine-2-ones series, ED50 indices for analgesic activity are in the dose range from 0.058 to 1.500 mg/kg, all tested compounds by analgesic activity values exceeded the reference preparation, diclofenac sodium.
The obtained data indicate the prospects of a series of the compounds studied in terms of finding and creating new effective analgesic and anti-inflammatory agents.