We give a theoretical and experimental study of the analgesic activity of non-steroidal anti-inflammatory drugs (NSAIDs) (diclofenac sodium, celecoxib and meloxicam lornoxicam) in experimental allergic encephalomyelitis equivalent during therapy with methylprednisolone. It was established that in intact animals all combinations of methylprednisolone and NSAIDs can influence the formation of the central component of the nociceptive response model electrocutaneous irritation root of the tail. However, in experimental allergic encephalomyelitis equivalent, the greatest potential anesthetic was showed by meloxicam (+186% (p£0.05)) and lornoxicam (+174% (p£0.05)) at the level of the central mechanisms of pain perception during electrostimulation of rat tail against the background of basic therapy with methylprednisolone.
