The influence of prolonged immobilization stress on stress-response development and prooxidative/antioxidative balance in myocardial and brain mitochondria of rats was studied. It has been shown that during the first 7 days of immobilization the intensity of lipid peroxidation and the amount of superoxide in mitochondria increased, which led to consequent rise in antioxidant enzymes activity. Further immobilization exhausted antioxidant defense and caused significant intensification of oxidative processes. This response of antioxidant system was correlated with dynamics of changes in blood corticosterone concentration.
