Cardioprotective effect of imidazo[1,2-a]azepinium derivatives on isolated rat heart has studied to assess their ability for myocardium preconditioning. Experimental compounds increased contractile activity of hearts in dose-dependent manner. At the same time, coronary flow decreased. Compounds exert effects in concentrations of 5×10-7, 1×10-6, 1×10-5 mol/l which reveal their high biological activity.
