The effect of bovine serum albumin (BSA) immunization on the meiotic maturation of oocytes, viability of the ovarian follicular cells, thymus-derived lymphocytes and lymph nodes cells and damage of the genome’s integrity of immune cells in female mice were investigated.
Thus, under the condition of BSA immunization oocytes damage, namely the suppression of meiotic maturation, reduction of the number of living cells of lymph nodes, thymus and follicular cells surrounding oocytes, nuclear DNA damage of the thymus and lymph nodes cells were observed.
We suggest that BSA immunization could modify the activity of gene expression associated with reparation displayed as single-strand DNA break.