The main plant and household allergens, which cause sensitization of patients in the Southern region of Ukraine, were revealed in the article. Among the causative-significant plant allergens, the highest rates were recorded for antigens of late flowering plants — ambrosia and mugword ((29.2±1.91)% and (21.60±1.73)% respectively, p<0.01) and early flowering — dandelion ((16.90±2.82)%). Among household allergens, the highest percentage of detection of antibodies was recorded to mould Alternaria alternata ((28.00±1.65)%, p<0.01) and mites Acarus siro ((25.50±2.00)%, p<0.01) and D. pteronyssinus ((22.20± ±1.53)%, p<0.01). Polysensibilization was registered in (81.10± ±1.69) % of patients.
