The aim of the study was the analysis of propoxazepam anticonvulsive action on the model of pentylenetetrazole-induced kindling in mice, and various seizures redistribution dynamics characterization.
Animals of the contol group were receiving pentylenetetrazole for 29 days subcutaneously, while those of experimental groups were administered prior to it (30 min before) with propoxazepam (2.0, 1.0, 0.6 and 0.2 mg/kg) intraperitoneally. The number of different severity seizures and time of their appearing after chemoconvulsive agent administration were recordered. The contribution of varying severity seizures into the total convulsive readiness, as well as the seizure index, was determined.
It has been found that administration of propoxazepam low doses (0.2–0.6 mg/kg) in the period of kindling formation does not have a significant anticonvulsant effect, although the manifestation of third and fourth severity degree seizures was inhibited. Propoxazepam high doses (1.0–2.0 mg/kg) inhibit the development of highest severity convulsions. When high doses are administered (2.0 mg/kg), there is practically no seizure even in the second severity degree. Based on the results of the dispersion analysis, the contribution of the propoxazepam dose factor to the model of kindling epilepsy ranges from 11.8% to 51.9% (for doses of 0.2–2.0 mg/kg).