In the patients with chronic viral hepatitis C (CVHC) different disturbances of the protein-synthesizing and detoxication hepatic functions as well as the symptoms of cytolysis and cholestasis, especially when combined with HIV infection, have been observed. In the HIV-infected patients without CVHC the hepatic function was intact. The course of antiretroviral therapy by lopinavir and ritonavir has significantly reduced the level of HIV-viral loading and significantly increased the level of CD4 + T-cells in HIV-infected, while the presence of concomitant CVHC worsened the effectiveness of antiretroviral therapy. The course of antiretroviral treatment slightly improved detoxication and protein-synthesizing hepatic functions; also it has a tendency to inhibit the cytolysis and cholestasis processes in the patients with HIV and CVHC co-infection.
