It was investigated the amino acid metabolism in descendants from the radiation-exposed animals. It was established that in descendants from animals, irradiated at dose 0.5 Gy, the system of creatine synthesis wasn’t impaired significantly, but with increasing of radiation dose to 1.0 Gy radioresistance and working capacity of rats progressivly decreseases as a result of accumulation of precursor creatine synthesis in the blood and urine. Irradiation of 1-month-old descendants, born from radiation-exposed animals at dose 1 Gy, gives evidence about the increasing sensibility to radiation injury, which finds its representation in lethality rate, reduced life expectancy and also in sympathoadrenal system malfunction, which accompanies increasing concentrations amino acids-precursors of catecholamines in the blood and urine. Tendency to increasing amino acid concentration in the blood and urine allows to assume diminution of inolving amino acids to creatine and catecholamine syntheses and decreasing usage of essential amino acids by radiation-exposed organism.
