Investigations have been perfomed on male mice weighing 18–24 g and rats weighing 180–350 g. Leptin was injected at a dose of 10 and 20 nM in a buffer solution to experimental animals. Study of the anticonvulsant activity in mice revealed that the hormone leptin protects 33% of animals against tonic-clonic seizures induced Corazol (116 mg/kg). In the open field the hormone leptin did not show sedative effects and did not change the locomotor activity of animals. When leptin administration at a dose of 10 nM when studying the influence on the short and long term memory in the Morris water maze test it was found that leptin lead to an improvement in both short and long-term memory in rats.
