In this work we have researched the cellular response of the living organism, which included: the dynamics of the blood cells content and hemoglobin, determination of WBC in the experiment dynamics, and after its completion, the study of indicators of cell membrane phospholipids. The experiment was conducted on white Wistar rats after oral priming aqueous solutions of surfactants. The tested doses were 1/1000, 1/100, 1/10 DL50. As a result of the long-term experiment (45 days) the change was indicated in the ratio of blood cells after exposure to half-lethal dose. Unstable increasing of the concentration of the lipid fractions of erythrocyte membranes to the 45th day of the experiment, suggesting that there is a dysfunction of the membranes was detected. The effect of morphofunctional cell response was analyzed on the 45th day of the experiment, which was formed by the new pool of reduced white blood cells, providing immune-physiological resistance of damaged cells.
