Effects of most perspective compounds — derivatives of 4-thiazolidinones — Les-1205 — ethyl ester of ([2,4-dioxo-5-(thiazol-2-ylkarbamoylmethyl)-thiazolidin-3-yl]-acetic acid and Les-2658 — (5-(-nitrobenzyliden)-2-(thiazol-2-imino)-4-thiazolidinone upon swimming of pentylenetetrazol (PTZ) — kindled rats have been investigated. The net reduction of the number of animals with passive adaptive type of swimming was observed in kindled group — from 3 out of 16 in intact rats up to 11 out of 15 in kindled one. The significant increase of the investigated index was seen after Les-1205 injection in dose of 100.0 mg/kg, i. p. — up to 10 out of 16 and axitinib in a dose of 20.0 mg/kg, peroral — up to 7 out of 10. The combined usage of Les-1205 and axitinib in doses which were not effective (25.0 and 50.0 mg/kg; 5.0 mg/kg correspondently) was resulted in significant rise of the investigated index — up to 6 out of 9 and up to 8 out of 11 correspondently. The combined administration of Les-2658 (50.0 mg/kg) and axitinib (5.0 mg/kg) was followed by index increase up to 8 out of 12 as well. Les-1205 (50.0 and 100.0 mg/kg), Les-2658 (100.0 mg/kg), as well as axitinib (10.0 and 20.0 mg/kg) facilitated the avoidance of kindled rats from the water. The significant increase of ability of rats to avoid the water was seen after combined administrations of Les-105, Les-2658 and axitinib in doses which were not effective (25.0 mg/kg and 5.0 mg/kg correspondently). Gained data are in favor for the additive effects of investigated drugs.
