In the experimental study there was examined the lead exposure on bone tissue of vertebral bodies of lumbar spine of rats with modeling osteoporosis by ovariectomy. Rats received lead acetate solution (230 mg/L) in distilled water for 2.5 months and were removed from the experiment at the age of 12.5 months. Lead exposure in rats with osteoporosis causes an increase in its content in the vertebral bodies on the background of osteoporosis 1.23 times. It was showed a reduction in vertebral bodies of the trabecular bone area and width of trabeculae at 31.93 and 13.92% respectively, and increased distance between trabeculae at 31.75%, indicating that the influence of lead impaired of trabecular bone quality. As a result of lead exposure in rats with modeling osteoporosis there increased the of the resorption process and inhibited bone formation in vertebral bodies.
