Tyrosine-kinase B activity plays the critical role in both pentylenetetrazol (PTZ) — induced kindling development and BDNF action upon seizure activity. BDNF administration induces both activation and inhibition of seizures, and it’s level is regulated along with brain electrical stimulations (ES).
Aim of the work was confined to the investigation cerebellar ES effects upon PTZ-induced kindled seizure activity at the background of tyrosine-kinase B activity inhibition with axitinib.
Combined usage of not-effective dosage of axitinb (5.0 mg/kg) and paleocerebellar ES (5 trials) prevented behavioral and electrographic seizures, induced in kindled rats with testing dosage of PTZ (30.0 mg/kg, i. p.).