Two weeks after the reproduction of the model of streptozotocin-induced diabetes mellitus in rats it was noticed a significant activation of lipid peroxidation of the erythrocyte membranes and hepatic mitochondrias that was proved by significant increasing in the content of diene conjugates, malonic dialdehyde and lipid hydroperoxides. Along with this, the enzymatic component of the anti-radical protection, namely, the activity of superoxide dismutase, catalase and the content of reduced glutathione significantly dropped. Non-enzymatic component of anti-radical protection was suppressed as well (according to tocopherol level). At the same time, a decrease in the peroxidative resistance of erythrocytes and total peroxidase activity of rats’ blood plasma had been recorded as an integral indicator that witnessed a disturbance of lipids metabolism. Curative-preventive administration of insulin and niacin-oxyethylidendiphosphonatogermanate (MIGU-4) alone has decreased to a certain degree a negative influence of diabetes mellitus on lipids peroxidation and anti-radical protection. Concomitant administration of these agents significantly prevented the disturbances of lipids metabolism in cellular membranes.
